Enhancing Oral Bioavailability

Transporters play an important role in the absorption of nutrients from the diet. They take up complex organic molecules and also enable absorption of important drugs. XenoPort has identified several high-capacity transporter proteins that are highly expressed and capable of transporting large quantities of complex organic molecules.

Antibody Detection of a Transporter That Is
Highly Expressed in the Colon

We believe that building Transported Prodrugs™ that are recognized by high-capacity nutrient carriers enables us to make the following advances in the bioavailability of oral drugs:

• Improve the efficiency and consistency of oral absorption.
• Impart colonic absorption to those drugs that cannot be delivered via sustained-release dosage forms.
• Potentially convert injectable drugs into oral forms.